Predicting muscle tissue response from calibrated component models and histology-based finite element models

نویسندگان

چکیده

Skeletal muscle is an anisotropic soft biological tissue composed of fibres embedded in a structurally complex, hierarchically organised extracellular matrix. In recent work (Kuravi et al., 2021) we have developed 3D finite element models from series histological sections. Moreover, based on decellularisation fresh samples, novel set experimental data the direction dependent mechanical properties collagenous ECM was established (Kohn 2021). Together with existing information material single fibres, combination these techniques allows computing predictions composite response. To this end, inverse procedure proposed present to calibrate constitutive model matrix, and supplementary biaxial tensile tests decellularised tissues are performed for validation. The results rigorously predictive thus unforgiving strategy suggest that prediction response individual characteristics cells only possible within clear limits. While orders magnitude well matched, qualitative behaviour wide range load cases largely captured, deviations point at potentially missing components highlight incomplete bottom-up multiscale approaches skeletal tissue.

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ژورنال

عنوان ژورنال: Journal of The Mechanical Behavior of Biomedical Materials

سال: 2021

ISSN: ['1751-6161', '1878-0180']

DOI: https://doi.org/10.1016/j.jmbbm.2021.104375